NONE 20260511092205973 wseas/wseas content-registration-form+ja@crossref.org content-registration-form WSEAS TRANSACTIONS ON BIOLOGY AND BIOMEDICINE 1109-9518 2224-2902 Sofia E. Mikhtaniuk ITMO University St. Petersburg RUSSIA Valerii V. Bezrodnyi St. Petersburg State University St. Petersburg RUSSIA Irina A. Karpushkina ITMO University St. Petersburg RUSSIA Alexey Yu. Vakulyuk ITMO University St. Petersburg RUSSIA Igor M. Neelov ITMO University St. Petersburg RUSSIA Oleg V. Shavykin ITMO University St. Petersburg RUSSIA Previously, it was shown that several short bioactive peptides, containing GluAsp (ED) sequence, can modulate gene expression and promote normalization of the function of different organs. In this work, we use Molecular dynamics simulations of the interaction between bioactive GlyGluAsp (GED) peptide molecules and a second-generation lysine dendrimer containing arginine-histidine (ArgHis) spacers. 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