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        <full_title>WSEAS TRANSACTIONS ON MATHEMATICS</full_title>
        <issn media_type="print">1109-2769</issn>
        <issn media_type="electronic">2224-2880</issn>
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        <titles>
          <title>A Novel Test for the Homogeneity of Several Covariance Matrices in High-Dimensional Data: Application to Gene Expression Analysis</title>
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        <contributors>
          <person_name sequence="first" contributor_role="author">
            <given_name>Saowapa</given_name>
            <surname>Chaipitak</surname>
            <affiliations>
              <institution>
                <institution_name>Department of Statistics, Faculty of Science, Kasetsart University, Bangkok 10900, THAILAND</institution_name>
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          <jats:p>This paper introduces a new test for the homogeneity of several covariance matrices in high-dimensional data under the p-variate normal distribution. The test is constructed using U-statistic-based estimators to evaluate differences among covariance matrices, and applies an inverse-variance-weighted method to quantify the relative importance of these estimators. Its distribution under the null hypothesis is derived and follows a chi-square distribution as the dimension and sample sizes increase. Simulation results indicate that the test controls the Type I error rate better than three existing methods and achieves high power. To demonstrate its practical applicability, two real gene-expression datasets involving three- and four-group comparisons are analyzed.</jats:p>
        </jats:abstract>
        <publication_date media_type="print">
          <month>04</month>
          <day>29</day>
          <year>2026</year>
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          <month>04</month>
          <day>29</day>
          <year>2026</year>
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        <pages>
          <first_page>36</first_page>
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          <item_number item_number_type="article_number">5</item_number>
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          <doi>10.37394/23206.2026.25.5</doi>
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