WSEAS Transactions on Biology and Biomedicine
Print ISSN: 1109-9518, E-ISSN: 2224-2902
Volume 12, 2015
Computer Simulation of Lysine Dendrimers and their Interactions with Amyloid Peptides
Authors: , , ,
Abstract: Computer simulation of lysine dendrimers and their interactions with short amyloid peptides were performed by molecular dynamic method. The size, anisotropy and structure of these dendrimers at different temperatures were calculated. It was shown that behaviour of lysine dendrimer itself is different from behaviour of many other dendrimers. It was also demonstrated that stack of eight amyloid peptides (Ab17-22) is stable but peptide dendrimer destroys this stack and adsorbs the peptides. The structure of dendrimer-peptide complex was studied. The mechanism of destruction of amyloid fibrils by positively charged dendrimers is suggested. These process probably could be used in future for curing Alzheimer’s disease.
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Pages: 79-86
WSEAS Transactions on Biology and Biomedicine, ISSN / E-ISSN: 1109-9518 / 2224-2902, Volume 12, 2015, Art. #11