Abstract: This study combines a multidisciplinary framework aligning human, wildlife, and environmental health to prevent future zoonotic pandemics. It highlights how integrating advanced digital innovations (artificial intelligence, IoT, blockchain) with a One Health approach enhances vaccine distribution, surveillance, and equitable access. Through a comprehensive review of vaccine supply chain research and case modelling, the analysis demonstrates that secure digital tracking and data integration can optimize logistics, enhance early warning systems, focus resources on high-risk interfaces, and inform proactive interventions. By combining cross-sector data and technology, this framework protects human and wildlife communities and reduces the broader socioeconomic impacts of emerging outbreaks. The findings underscore the importance of cross-sector collaboration: the integration of technological tools with coordinated human-animal-environment policies can significantly strengthen pandemic preparedness and improve resilience against global public health threats.

Keywords: Zoonotic diseases prevention, Vaccine supply chain, One Health approach, Wildlife vaccination, Pandemic prevention strategies, Multidisciplinary collaboration, Supply chain optimization models, Environmental health alignment, Pharmaceutical industry involvement, Vaccine hesitancy and misinformation

Pages: 1066-1081